Alteplase dose in cardiac arrest due to pulmonary embolus

Report By: Dr. Meghan Ryall - ED SMO
Institution: Whakatane Hospital, New Zealand
Date Submitted: 18th October 2020
Last Modified: 2nd November 2020
Status: Red (incomplete)

Three Part Question

[In patients with cardiac arrest from PE] does
[a 50 mg IV bolus of Alteplase compared to 100mg given IV over 2 hours] improve [survival rates to ROSC or hospital discharge (any neurologic outcome) without increased risk of stroke/bleeding?]