Can a high sensitivity Troponin T rule out Acute Coronary Syndrome taken at 0-hour and 1-hour after presentation?

Report By: Nil Kamal Samanta, Adrian Marsh, Samik Kumar Bandyopadhyay - Consultant ED, Consultant ED, Doctor Upper GI Surg
Search checked by Nil Kamal Samanta - Consultant, Emergency Medicine
Institution: Shrewsbury and Telford Hospitals NHS Trust
Date Submitted: 29th January 2018
Last Modified: 30th January 2018
Status: Blue (submitted but not checked)

Three Part Question

In [an adult over 18 years of age presenting with low risk cardiac pain] is a [high sensitivity Troponin T (hs-cTnT) taken at 0-hour and 1-hour after presentation] sensitive enough to [rule out Acute Coronary Syndrome (ACS).]

Clinical Scenario

A 45-year-old man attended the Emergency Department (ED) with one-hour history of chest pain that could be of cardiac origin. His ECG did not reveal acute ischemic changes. It is important to substantiate or rule-out ACS in this situation. This analysis is aimed at finding whether a hs-cTnT measurement taken at 0-hour and 1-hour after presentation is sensitive enough for this purpose.

Can a high sensitivity Troponin T rule out Acute Coronary Syndrome taken at 0-hour and 1-hour after presentation?

Three Part Question

Clinical Scenario

Search Strategy