Platelet Transfusion in Patients with Traumatic Intracranial Hemorrhage on Antiplatelet Therapy

Report By: Jean-Sébastien Audette - PGY 4, Emergency medecine
Institution: Université Laval, Québec
Date Submitted: 24th November 2011
Last Modified: 6th March 2013
Status: Blue (submitted but not checked)

Three Part Question

In [patients on antiplatelet therapy suffering froma traumatic intracranial hemorrhage],does [platelet transfusion] improve [survival]?

Clinical Scenario

An unconscious 67-year-old male involved in a motor vehicle accident is brought to the emergency departmentby paramedics. The head CT shows a frontal contusion. The patient is on Clopidogrel. You wonder if the antiplatelet therapy reversal with platelet transfusion would improve patient’s survival.

Search Strategy

A. No BestBETs or critical appraisals were found on this topic.
B. There was no Cochrane review found on the subject.
C. www.clinicaltrials.gov was searched for an ongoing trial on the topic andnone was found.
D. Medline 1900 to December 15 2012 via Pub med :

1. \\\"Intracranial Hemorrhages\\\"[Mesh] : 51770
2. \\\"Platelet Aggregation Inhibitors\\\"[Mesh] : 24039
3. \\\"Platelet Transfusion\\\"[Mesh] : 4275
4. \\\"Wounds and Injuries\\\"[Mesh] : 652 943
5. 1 AND 2 AND 3 AND 4 :7

1 relevant article

E. Embase>1946 to December 15 2012 :

1. Thrombocyte Transfusion : 9 906
2. Brain Hemorrhage : 77 790
3. Antithrombocyticagent : 244 010
4. Injury : 1 591 609
5. 1 AND 2 AND 3 :61

2 relevant articles(1 new article)