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Does a teething child need serious illness excluding?

Three Part Question

In [an infant with suspected teething] are there [any symptoms or signs pathognomonic of teething] that would allow for [the reassurance of parents without further management]?

Clinical Scenario

An 8-month-old girl has been referred to the emergency department by her general practitioner with a 24-h history of drooling, intermittent screaming and low-grade fever (maximum 38.2°C). She is refusing solids and her fluid intake has decreased. Her parents report that her nappies are drier than normal but her stools are looser. She has had some relief from oral paracetamol syrup. Her parents suspect teething.
On examination she is found to be miserable. She is not clinically dehydrated and has a diffusely hyperaemic right cheek. On examination of her mouth you notice a raw area on her upper gums where two teeth are erupting. No other abnormal clinical signs are noted.
You agree that the infant may be teething, but wonder if there are any symptoms that would distinguish between teething and an alternative diagnosis.

Search Strategy

Medline (1966–September 2006) using the OVID interface
keywords "(teething or tooth) and symptom$ and (infant or baby)". Limits included human and English language only.

Search Outcome

In total, 78 articles were identified, of which teething was the main focus in 21 articles. There were three prospective studies and two retrospective studies examining the link between teething and systemic symptoms in the community (table). These form the basis of our evidence-based review. Another retrospective review presented the diagnoses of 50 children admitted to hospital with a presenting complaint of teething. This is discussed separately (Wake, 2002).
One previous letter commented on the three prospective trials (South) Nine articles found were questionnaire studies on beliefs of local populations (both health professional and parental) regarding teething. Studies not discussed here include cytokine levels in the gingival area (n = 1), effects of mercury exposure on teething (n = 1), misuse of teething gel (n = 1), herpes stomatitis mimicking teething (n = 1), and a nursing article on teething that was purely descriptive. One article summarised the study by Wake et al (Frank) and is also not discussed.

Relevant Paper(s)

Author, date and country Patient group Study type (level of evidence) Outcomes Key results Study Weaknesses
Wake et al,
21 children from 3 day-care nurseries assessed over 2067 days. 90 teeth erupted during the study periodLevel 1b: prospective cohort study with objective assessmentDaily assessment for 7 months by independent practitioner, including temperature and gum examination with daily symptom questionnaire recorded independently by parents and staffNo association between teething and fever, mood disturbance, appearance of illness,sleep disturbance, drooling, diarrhoea,strong urine, red cheeks, or rashes/flushing on the face or body. Parental data suggested an association between loose stools and teething, but this was not seen in data from assessing staff78% enrolment rate. 6% of dental therapist and 13% of day-care staff data not available.Mean age of children enrolled = 14.4 months. This is the only study with an objective assessment of teething and a clear definition of teething. No description of statistical method, but logistical regression used in results
Macknin et al,
125 infants enrolled at 4 months assessed over 19 422 days. 475 teeth erupted during study periodLevel 2b: prospective cohort study with parental assessmentTwice-daily assessment for 8 months by parents, including temperature and gum examination with daily symptom questionnaire recorded by parentsSymptoms significantly associated with teething: increased biting, drooling, facial rash, irritability and fever (all <38.3°C). No symptom occurred in >35% of infants during the teething period; no symptom occurred in >20% more often in the teething period than in the non-teething period. No symptom reliably predicts teething. Diarrhoea/cough/vomiting/fever >38.9°C not associated. No serious illnesses25% enrolment rate —presumably only highly motivated families 14 (>10%) of families enrolled provided no information. No objective assessment of tooth eruption. Power study and appropriate statistical method presented.
Jaber et al,
46 infants enrolled prior to first tooth eruptionLevel 2b: prospective cohort study with parental assessmentDaily assessment by parents, including temperature and gum examination with daily symptom questionnaire recorded by parents Presentation with tooth eruption confirmed objectively Data from 20 days preceding tooth eruption used for analysisSignificant difference in temperature, using 37.5°C as a cut-off value, was found between day of tooth eruption and preceding days (2 test p<0.025)Parents blinded as to reason for daily symptom recording, but asked to present child when tooth eruption suspected. No discussion of prevalence of other symptoms Temperature data analysed with discontinuous statistics
Peretz et al,
585 children assessed at clinic (145 infants with erupting teeth, 357 controls)Level 3b: retrospective –case control studySingle clinical assessment of tooth eruption. Retrospective questionnaire completed by parents40% of teething children were asymptomatic. 93% of control children were asymptomatic. 60% of children had at least one of the following symptoms reported: drooling (32%), fever >39°C (25%), diarrhoea (35%) Presence of drooling and fever were assessed at clinic visitNo comparison of study and control groups. Data not presented on 83 children in control group (19%). No distinction between objective and reported symptoms. Temperature cut-off of >39°C used and analysed with discontinuous statistics
Cunha et al,
Records of 1813 children aged 0–3 years seen at dental baby clinicLevel 4: retrospective case seriesCase note analysis for specific symptoms associated with tooth eruption1165 records (64%) had sufficient information.95% of children had some symptoms associated with tooth eruption, but these included gingival itching and irritationNo control patients. No definitions of symptoms or signs. No ability to determine whether any results were significant


From this review, it is apparent that a number of children develop symptoms that their parents/carers attribute to teething. However, although our analysis shows that a variety of symptoms may occur contemporaneously with teething, there is no pattern of symptoms manifesting in all the studies that can reliably distinguish teething from any other potential cause of the symptoms. The most robust study by Wake et al (2000) did not confirm any notable association between teething and systemic symptoms. However, the mean age of the children enrolled was 14.4 months, which is older than that in other studies. The mean age of eruption of the first tooth, usually a lower incisor, is around 8 months and so this study may have missed the majority of first-tooth episodes. Peretz et al did analyse symptoms with respect to age, and although the data are retrospective their results suggest that teething symptoms peak around 12–15 months. The largest study by Macknin et al showed significant (p<0.01) associations with biting, drooling, gum rubbing, irritability, sucking and temperature >37.5°C. However, attributing these symptoms to teething was not possible as no symptom occurred in >35% of infants during each teething period, and no symptom occurred >20% more often in the teething period than in the non-teething period. The results presented by Jaber et al considered only temperature and only included children before the emergence of their first tooth. This was despite a daily record kept by the parents of a number of other symptoms, including diarrhoea. The data presented in graph form suggest that there is an increase in temperature at the time of the first tooth eruption, and the 95% confidence intervals (37.33°C to 37.86°C) exceeded the mean temperatures on days before the tooth eruption (37.1°C). However, there are no confidence intervals for the mean temperatures before the eruption, and it is not possible to determine the relevance of these data. The conclusions of all the prospective studies are that no specific symptoms or clusters of symptoms can reliably predict the emergence of a tooth. Furthermore, symptoms that might be attributed to teething are not serious, and the presence of fever (>38.5°C) or other clinically important symptoms are very unlikely to be caused by teething. This is borne out by Swann, who reviewed 50 children admitted to hospital with a presenting complaint of teething. In 48 children, a medical condition was diagnosed, including one case of bacterial meningitis. Nine studies assessed perceptions in certain populations from countries including Nigeria, Australia, Turkey, the USA, Israel and Guinea-Bissau. These studies are subjective and open to recall bias and hence are not included in the evidence base of this report. However, they do demonstrate the widely held secular view that teething can cause many clinical symptoms—for example, in the Guinea-Bissau population, only 33% of parents with "severely dehydrated" children would seek medical help if they thought that the dehydration was secondary to teething. On the other hand, teething may be a label for minor ailments and provide a rationale that parents can accept. This label may also provide confidence to the carers of children that the child can be managed without resorting to formal healthcare (Wake, 2000). Our critical appraisal found two large well-designed studies that show that teething is unlikely to be associated with relevant clinical symptoms and signs, and one smaller study which showed a possible association between temperature and the eruption of the first tooth. The two large retrospective studies were not sufficiently robust to provide further information. We also identified one paper highlighting the risks of attributing relevant medical symptoms to teething. This review suggests that there is no evidence that teething can be "identified" as the source of symptoms in a child. We agree with previous authors and recommend that this is a diagnosis of exclusion, to be made with caution. We acknowledge that this message may conflict with many firmly held beliefs of our patients' parents and of other colleagues, but this review has shown that if a child is ill enough to be admitted to hospital, other organic causes need to be excluded, so that the child is managed appropriately. We also suggest that visualisation of the gums should be part of the clinical examination of the mouth and pharynx in young children to deal with the possible parental concerns, as teething has often been diagnosed on the basis of symptoms alone.

Clinical Bottom Line

No evidence is available to suggest that there are any symptoms or signs specific to teething that allow a diagnosis to be made confidently in a child without excluding other organic pathology (grade B).


  1. Wake M, Hesketh K, Lucas J. Teething and tooth eruption in infants: a cohort study. Pediatrics 2000;106:1374–8.
  2. Macknin ML, Piedmonte M, Jacobs J, et al. Symptoms associated with infant teething: a prospective study. Pediatrics 2000;104:747–52.
  3. Jaber L, Cohen IJ, Mor A. Fever associated with teething. Arch Dis Child 1991;67:233–4.
  4. Peretz B, Ram D, Hermida L, et al. Systemic manifestations during eruption of primary teeth in infants. J Dent Child 2003;70:170–3.
  5. Cunha RF, Pugliesi DM, Garcia LD, et al. Systemic and local teething disturbances: prevalence in a clinic for infants. J Dent Child 2004;71:24–6.
  6. Swann IL. Teething complications, a persisting misconception. Postgrad Med J 1979;55:24–5.
  7. South M. On teething symptoms. BMJ 2003;326:282.
  8. Frank J, Drezner J. Is teething in infants associated with fever or other symptoms? J Fam Pract 2001;50:257.
  9. Bankole OO, Denloye OO, Aderinokun GA. Attitude, beliefs and practices of some Nigerian nurses toward teething in infants. Odontostomatol Trop 2004;27:22–6.
  10. Oyejide CO, Aderinokun GA. Teething myths in Nigerian rural Yoruba communities. Afr Dent J 1991;5:31–4.
  11. Denloye O, Bankole OO, Aderinokun GA. Teething myths among community health officers. Odontostomatol Trop 2005;28:19–22.
  12. Wake M, Hesketh K, Allen M. Parent beliefs about infant teething: a survey of Australian parents. J Paediatr Child Health 1999;35:446–9.
  13. Wake M, Hesketh K. Teething symptoms: cross sectional survey of five groups of child health professionals. BMJ 2002;325:814.
  14. Baykan Z, Sahin F, Bayazova U, et al. Experience of Turkish parents about their infants teething. Child Care Health Dev 2004;30;331–6.
  15. Barlow BS, Kanellis MJ, Slayton RL. Tooth eruption symptoms; a survey of parents and health professionals. J Dent Child 2002;69:148–50, 123-4.
  16. Sarrell EM, Horev Z, Cohen Z, et al. Parents and medical personnel's beliefs about infant teething. Patient Educ Couns 2005;57:122–5.
  17. Sodemann M, Jakobsen MS, Molbak K, et al. Management of childhood diarrhoea and use of oral rehydration salts in a suburban West African community. Am J Trop Med Hyg 1999;60:167–71.