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LMH v/s UFH in STEMI treated with thrombolysis

Three Part Question

IN [patients with STEMI treated with thrombolysis] IS [Unfractionated Heparin better than Low Molecular Weight Heparin] AT [preventing re-infarction]?

Clinical Scenario

A 65 yr of man presents to the ED with 30 min history of central cardic chest pain. His ECG is suggestive of STEMI. He is otherwise haemodynamically stable and has no contraindications for thombolysis. A desicion to thrombolysis was made. A question whether Unfractionated Heparin was better than Low Molecular Weight Heparin in thrombolysis

Search Outcome

443 papers were found. 2 were relevant to the question

Relevant Paper(s)

Author, date and country Patient group Study type (level of evidence) Outcomes Key results Study Weaknesses


  1. Eikelboom JW. Quinlan DJ. Mehta SR. Turpie AG. Menown IB. Yusuf S Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: a meta-analysis of the randomized trials irculation. 112(25):3855-67, 2005 Dec 20 112(25):3855-67
  2. Antman EM. Morrow DA. McCabe CH. Jiang F. White HD. Fox KA. Sharma D. Chew P. Braunwald E. Enoxaparin versus unfractionated heparin as antithrombin therapy in patients receiving fibrinolysis for ST-elevation myocardial infarction. Design and rationale for the Enoxaparin and Thrombolysis Rep American Heart Journal 49(2):217-26, 2005 Feb