Three Part Question
In [a young adult with mild to moderate pain from tension headaches] does [kapake or cocodamol offer better analgesia] in terms of [onset and duration of pain relief]?
A 27 year old female with a 2 day history of headache attends the A&E department. Clinical assessment of this patient comforms with a diagnosis of tension headaches. She was given Kapake for pain relief and discharged.
Medline using OVID interface 1966-6/98.
(exp acetaminophen/ or paracetamol.ti, ab, sh.) AND (exp codeine/ or codeine.ti, ab, sh.) AND (exp tension headache/ or exp headache/ or headache.ti, ab, sh.)
28 papers of which 1 Russian, 1 German, 19 not relevant and 6 not specific to the question.
|Author, date and country
||Study type (level of evidence)
|Friedman AP and DiSerio FJ|
|198 adults evaluated for Fioricet, acetaminophen with codeine and placebo.||PRCT multicentre||4 hrs assessment of pain relief, emotional tension and muscle contraction.||Active analgesics effective than placebo.||Different strength than used in UK.
Not comparing the analgesics in question.
Poor explanation of statistics.|
Regarding the proposed question there was no paper addressing the different strengths of codeine compound.
Clinical Bottom Line
Unable to make a comparison between kapake and cocodamol as to pain relief effectiveness.
- Friedman AP, DiSerio FJ. Symptomatic treatment of chronically recurring tension headache: a placebo-controlled, multicenter investigation of Fioricet and acetaminophen with codeine. Clinical Therapeutics 1987;10(1):69-81.