Author, date and country | Patient group | Study type (level of evidence) | Outcomes | Key results | Study Weaknesses |
---|---|---|---|---|---|
Mealy K et al UK 1986 | 61 patients with acute whiplash injury Cervical collar vs early active mobilisation | PRCT | Cervical movement at 8 weeks | Significantly better in mobilisation group (P < 0.05) | |
Intensity of pain at 8 weeks | Significantly better in mobilisation group (P < 0.05) | ||||
McKinney LA et al 1989 UK | 170 patients with acute whiplash injury Cervical collar (33) vs home mobilisation (66) vs physiotherapy (71) | PRCT | Severity of neck pain at 1 and 2 months | Mobilisation and physiotherapy significantly better than collar (P < 0.01) | Collar numbers small Rest group abandoned half way through trial |
Cervical movement at 1 and 2 months | Mobilisation and physiotherapy significantly better than collar (P < 0.01) | ||||
McKinney LA 1989 UK | 128 of 170 patients with acute whiplash followed up at 2 years Physiotherapy vs advice on mobilisation vs initial period of rest | PRCT | Proportion of patients with symptoms at 2 years | Significantly lower in advice alone group | 68% follow-up rate Rest group abandoned half way through trial All patients wore collars |
Proportion of patients with symptoms at 72 hours | No significant difference | ||||
Gennis P et al 1996 USA | 196 of 250 patients with whiplash injury following automobile crashes Cervical collar vs no collar and unsupervised mobilisation | PRCT | Pain at 6 weeks | No significant difference | Short follow up period |
Borchgrevink GE et al 1998 Norway | 201 patients with neck sprain that resulted from a car accident Cervical collar vs unsupervised mobilisation | PRCT | Neck movement at 14 days and 24 weeks | Significantly better in mobilised group | Only 69% of patients completed the trial |
Neck pain at 14 days and 24 weeks | Significantly better in mobilised group | ||||
Rosenfeld M 2000 Sweden | 97 patients with whiplash injury. Recruited from EDs and primary care. Active treatment involved the use of McKenzie principles. Patients randomised to either 1) active treatment, 2) active treatment after 14 days, 3) standard (rest with collar advised) treatment, 4) delayed standard (rest) treatment | PRCT | Mean number of sessions needed in active groups | 3.95 sessions | Relatively small numbers means that although there are trends towards changes in ROM differences the study has insufficient power to demonstrate them. Collars were not worn by all standard group patients. Those in the treatment group required several interventions. Costs of this not examined |
Reduction in pain at 6 months | Greatest in early active group (30% more with no pain). Worst with early standard treatment (minimal change at 6 months) p<0.001 | ||||
Range of movemenrt | Most improvement in early active group (non significant) | ||||
Active therapy: early vs late | Better if started early (p not given) | ||||
Standard (rest) therapy: early vs late | Worst if started early | ||||
Crawford JR 2004 England | 108 consecutive patients with soft tissue injury of the neck. Randomised to either early mobilisation with exercise or 3 weeks in a soft collar. Aged over 18 years. Analysis was by intention to treat. | PRCT | Requirment for additional physiotherapy | 35% for mobilisation vs 45% for collar p=NS | Randomisation method based on hospital notes number (even or odd). Collar group had lower scores at baseline suggesting that they may have had a more serious baseline injury. |
Time off work | 17.3 days for mobilisation vs. 34.4 for collar p=0.03 | ||||
Activities of daily living score (0-9) at baseline | 7.01 for mobilisation vs. 5.92 for collar p=0.07 | ||||
Activities of daily living score (0-9) at 3 weeks | 7.43 for mobilisation vs. 7.04 for collar p=0.43 | ||||
Activities of daily living score (0-9) at 12 weeks | 7.08 for mobilisation vs. 7.38 for collar p=0.2 | ||||
Activities of daily living score (0-9) at 52 weeks | 9.22 foe mobilisation vs. 9.33 for collar p=0.62 | ||||
Range of movement | No statistical or clinical differences found | ||||
Verhagen AP 2004 Not stated | Review of papers on the conservative treatment of whiplash. Extensive search of electronic databases and references of identified trials. Only RCTs included. Where data was unclear the authors reanalysed the original data, on occasions they came to different conclusions from the original authors. | Systematic review | Number of studies included | 15 RCTs found | Search could be more extensive for a systematic review. Other interventions were also examined but are not included her as not relevant to the 3 part question. Non standard method of assessing quality of trials. Although the authors of this review are cautious in their interpretation, their data suggests a consistent finding that active interventions are probably better. |
Study quality | Only 3 studies were considered high quality | ||||
Studies of active vs. passive interventions | High quality studies had conflicting results. Lower quality studies showed benefit to active treatments. | ||||
Rosenfeld M 2003 Sweden | 97 patients with whipash injury. This is a 3 year follow up of patients from a previous study detailed in the BET table. Active treatments were McKenzie based. Standard treatment included rest and collar. | PRCT Long term follow up. | Proportion with no pain at 6 months | 38% for early active, 17% for early rest, 23% for late active, 9% for late rest | 91% followed up for 6 months. 75% followed up for 3 years. Size of study makes changes in other outcomes (e.g. range of movement) difficult to demonstrate. |
Proportion with no pain at 3 years | 33% for early active, 33% for early rest, 44% for late active, 31% for late rest. | ||||
Days sick leave at 3 years | 11.2 for early active, 40.2 for early rest, 10 for late active, 20.5 for late rest | ||||
Range of movement at 3 years | Statistical analysis suggests better of patients treated actively. |